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Abstract

Rutin is a flavonoid glycoside that has shown wide range of pharmacological applications with various beneficial medical effects. Rutin is poorly soluble in water and could limit its absorption from the gastrointestinal tract. The aim of this project was to develop and validate a simple UV analytical method for the evaluation of Rutin release from tablet dosage form. The method was developed by testing solubility of Rutin in different concentrations of sodium lauryl sulfate. The dissolution method was then validated in accordance with international guidelines. The results showed that the best dissolution was achieved in phosphate buffer pH 6.8 containing 3% SLS. The percent released was almost 100% after 55 minutes. The developed method was found to be linear, precise and accurate in the range (0.04-0.1mg/ml). The analytical method was also found to be selective for Rutin. In conclusion we successfully developed a dissolution method that is easy and feasible. The validated analytical dissolution method could be used by quality control labs and could be adopted by the official international pharmacopeias.

Digital Object Identifier (DOI)

10.59049/2790-0231.1042

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