Lead toxicity is an important global public health issue. The present study was conducted to determine the amount of lead deposited in chicken blood after intentional exposure to a concentrated source of lead for 1 week and to determine the effect of 4 week daily supplementation with high dose ascorbic acid (AA) on the blood lead levels in broiler chicken. Clinically normal mixed-breed adult laying chickens were used in this study. Chickens received lead acetate (200 mg/kg/day) for 1 week. A group of chicken received AA (500 mg/kg/day) for 4 weeks. Another group did not receive any treatment for another 4 weeks. Blood samples were collected and analyzed for blood lead levels using a graphite furnace atomic absorption spectrophotometer. The baseline blood lead level was 47.5 ¬± 38.0 ¬µg/L and increased significantly to 2755 ¬± 576 ¬µg/L after 1 week of lead acetate treatment (P < 0.001). AA treatment reduced blood lead levels significantly (P < 0.05). Supplementing lead-contaminated feed with daily high doses of AA might protect from lead exposure when chickens are exposed to environmental pollution.
Shawahna, Ramzi; Zyoud, Ahed; Shehadeh, Suheir; Idkeidek, Tamara; Abu-Rwess, Sawsan; Abubaker, Omar; Abd-Aldaym, Mohammad; and Hilal, Hikmat S.
"Effects of Daily Supplementation with High Dose Ascorbic Acid on Blood Lead Levels in Broiler Chicken after Intentional Exposure to a Concentrated Source of Lead,"
Palestinian Medical and Pharmaceutical Journal: Vol. 1:
1, Article 4.
Available at: https://pmpj.najah.edu/journal/vol1/iss1/4