It was estimated from World Health Organization (WHO) that most of the world population depends on herbal medicine for their health care. Azadirachta Indica A.Juss also known as neem plant is one of the most popular medicinal plants in Asia and Africa which was used from the anceint times for many medicinal purposes. It is used in many traditional remedies because of its richness with biological active constituents. Some of these chemical constituents are Nimbidin, Nimbin, Nimbolide, Gedunin, Azadirachtin, Mahmoodin, Cyclic trisulphide and others which are used as antipyretic, anti-inflammatory, antibacterial, antigastric ulcer, antiarthritic, spermicidal antifungal, antimalarial, hypoglycemic, immunomodulatory, diuretic and antitumour. Traditionally differnet parts of the plant are used by populations from many countries for the treatment of several diseases such as leprosy, epistaxis, eye problem, elimination of intestinal worms, anorexia, skin ulcers, biliousness, skin diseases like ringworms, burning sensation, wounds and itching. It is also used as analgesic, alternative and curative of fever and urinary disorder. In addition, it is used in the treatment of cough, asthma, phantom tumour, spermatorrhoea, diabetes, blood morbidity, biliary afflictions and many more medicinal values. The present work provides comprehensive information on the traditional use value and the chemical constituent of Azadirachta Indica in order to explore the therapeutic potential, highlight the relation between the traditional use value and the chemical constituents and the scientific future research opportunities on Azadirachta Indica

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