The purpose of this study is to investigate the adherence to the management of Type I Diabetes and to investigate factors associated with non-adherence among Palestinian Type 1 Diabetes patients. One hundred and twenty-six patients diagnosed with Type 1 Diabetes were enrolled in an observational cross-sectional study. Diabetes self-care adherence was meas-ured using the Self Care Inventory (SCI). The patients were recruited from a diabetes clinic in Nablus city in Palestine. One-way ANOVA test and simple linear regressions were used in the statistical analysis. Participants age ranged from 3-43 years; 56% of them were females. The mean age at diagnosis for them was 10 years (+/-6.25). The mean glycosylated hemoglobin (A1C) was 9 +/-2.32. 66% of patients reported significant non-adherence to glucose testing, 89% reported non-adherence to diet recommendations, 79% reported non-adherence to exer-cise, and 21% reported non-adherence to administering insulin on time. Age (r = 0.29, P < 0.05), A1C (r = 0.21, P < 0.05), sex (P < 0.05), and patient educational level (P< 0.05) were significantly related to adherence score. Adherence to treatment among pa-tients with Type 1 Diabetes is poor and is associated with age, sex, A1C, and patient educa-tional level. Designed education programs should be implemented among patients with Type 1 Diabetes, which address the importance of adherence to the management of the diseases. More strategies should focus on monitoring the diet and insulin administration.

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