Introduction: Nonsteroidal anti-inflammatory drugs are the most common drugs as a prescription or over-the-counter drugs, and acute kidney injury (AKI) is one of the dangerous complications of these drugs. This research aims to assess the risk and effect of nonsteroidal anti-inflammatory drugs on kidney outcomes. Methods: In the prospective analytic (experi-mental) study type with randomized clinical trial design and article type of systematic review and meta-analysis, 32 patients with nonsteroidal anti-inflammatory drug-induced nephropa-thy were enrolled. The prevalence of complications, relative risk, and odds ratio as effective measures of endpoints were assessed in the present research. Results: Of 32 patients in non-steroidal anti-inflammatory induced nephropathy, 16 patients (16/32, 50%) were male, and sixteen patients (16/32, 50%) were women. AKI was the most common complication of these drugs (14/32, 43.7%), and the prevalence of diclofenac sodium was 34.3% (11/32) as the most common drug in the induction of nonsteroidal anti-inflammatory drugs nephropathy. Relative risk and odds ratio of AKI in patients with nonsteroidal anti-inflammatory induced nephropathy were evaluated at 0.94 with 95% confidence level of 0.09803 to 6.247 and 0.75 with 95% CI of 0.06368 to 8.8339, respectively. Conclusion: Nonsteroidal anti-inflammatory drugs were accompanied by low risk and Odds ratio of AKI in the present investigation. In the present research, diclofenac sodium was reported as the most common drug in nonsteroi-dal anti-inflammatory-induced nephropathy.

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