The medicinal properties of spice plants have been recognized for centuries due to the essential oils obtained from these plants, which are considered therapeutic agents and have shown various therapeutic effects. Coriandrum sativum (C. sativum) seed oil was extracted using the organic solvent method and then examined for its antidiabetic (using the anti-amylase assay), antiobesity (using the anti-lipase assay), and antioxidant activities (using the DPPH inhibition assay) by in vitro methods. As observed, C. sativum seed oil showed a strong anti-amylase effect with an IC50 equal to 79.43 ±1.50 µg/ml compared to acarbose, which had an IC50 equal to 28.1 ±1.13 µg/ml. The strong anti-elastase effect of C. sativum oil was also reported with an IC50 equal to 25.08 ±1.23 mg/ml compared with the IC50 value of oleanolic acid (the IC50 of oleanolic acid is 25.09 ±0.09 µg/ml). In addition, potent antioxidant activity with an IC50 equal to 17.78 ±1.62 µg/ml was compared to the Trolox, which had an IC50 equal to 2.7 ±0.07 µg/ml. On the other hand, moderate to weak effects as antiobesity agents were reported with an IC50 equal to 91.20 ±1.27 µg/ml compared to orlistat, which had an IC50 equal to 12.09 ±0.09 µg/ml. This study confirms the traditional use of the seeds of C. sativum as a natural remedy for diabetes, oxidative stress conditions, and some skin disorders. Further in vivo investigation must be conducted in the future.

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