Diacerein is an anti-inflammatory drug used to treat osteoarthritis. Available dosage forms of diacerein cannot reduce its main adverse effects like soft stool and diarrhea. The main aim of this work is to evaluate the antiarthritic effects of diacerein microsphere in the complete Freund's adjuvant (C.F.A.)-induced arthritis model in rats and on intestinal meal transit and peristaltic index. Diacerein microspheres were administered to experimental rats via oral routes. Five experimental groups of Sprague Dawley rats were considered: Group I (Negative control group), Group II (Positive control group), Group III or test group (Diacerein microsphere treated group), Group IV or Standard I group [Diacerein API (active pharmaceutical ingredient) treated group], Group V or Standard II group (Glucosamine treated group). Glucosamine was considered a standard drug because it has a similar mechanism of action to diacerein (IL-1β inhibition), and various literature reviews showed that it has antiarthritic and cartilage protective effects. Various antiarthritic effects like paw volume, joint stiffness, arthritic index, gait test, body weight measurement, and X-ray of tibiotarsal joints were evaluated in test group rats and compared to standard I standard II group. The Diacerein microsphere-treated group showed similar results compared to the standard I and II groups. A charcoal meal test was performed on fresh, experimental animals, and results showed that the diacerein microsphere causes the sustained release of diacerein so that diacerein-mediated diarrhea is reduced.

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