Several studies have shown gender variations in acute coronary syndrome's clinical presentation, diagnosis, therapy, and outcomes. Both immediate and long-term outcomes were worse for women with the acute coronary syndrome than men. This study investigates the influence of sex differences on the clinical presentations, treatment approaches, and patient outcomes of acute myocardial infarction at a large tertiary hospital in Palestine. A retrospective cohort study included all patients with acute myocardial infarction who presented to An-Najah National University Hospital from January 2018 to December 2020. Of the 422 patients in this study, 96 (22.7%) were women. Compared to men, women were older (p <0.001) and had significantly higher rates of diabetes mellitus (p <0.001) and hypertension (p <0.001). Additionally, women had greater chances of complaining of atypical cardiac chest pain (p = 0.012). Furthermore, non-ST segment elevation myocardial infarction was more prevalent among women (p = 0.017). Regarding the hospital course, the median number of stents was statistically significant in men (p = 0.029), but women had significantly higher in-hospital mortality (p = 0.013) and a higher rate of blood transfusion (p = 0.026). Myocardial infarction presents differently in males and women. Women were older, had more comorbid conditions than men, had atypical presentations, and had higher in-hospital mortality rates. As a result, while evaluating and treating patients suspected of having a myocardial infarction, healthcare practitioners must account for these discrepancies to reduce the mortality rate among women.

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