Stenotrophomonas maltophilia, a gram-negative nonfermenter, is ubiquitous in the environment and has the propensity to colonize devices and even the respiratory tract. The organism shows intrinsic resistance to multiple drugs commonly used in hospitals, like cephalosporins, carbapenems, and aminoglycosides, thus selecting this organism from endogenous patient flora. Here we conducted a retrospective study presented as a case series to share our experience in our setup. We encountered 9 cases during 1 year, most sensitive to levofloxacin and minocycline. All the cases apart from two were discharged successfully following the appropriate regimen. The mean age of patients was 50 years, and most patients had a history of long-standing diabetes. Most of the cases were admitted to ICU and were on ventilators. The organism commonly causes ventilator-associated pneumonia in our series. Our area lacks studies on this organism, which is rising in prevalence. Thus, further large-scale studies are needed to ponder this infection's prevalence and increasing resistance of this organism to TMP/SMX (Cotrimoxazole), the drug of choice in this infection.

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