Objective: The study aimed to assess the results of stenting in unprotected left main coronary artery disease (uLMCAD) at a tertiary hospital center. Methods: We assessed all patients who received stenting for uLMCAD, including stable patients who underwent elective, urgent, or emergent procedures. Data were gathered by reviewing hospital records and coronary angiograms and calculating SYNTAX scores. Patient follow-up was conducted via clinic visits and phone calls. Results: Percutaneous coronary intervention (PCI) was performed on seventy patients with uLMCAD, all of whom had successful revascularization. During their hospital stay, only one patient (1.4%) died from a noncardiac cause and no patient experienced target lesion failure. After an average follow-up of 17.4 ± 12.36 months, four patients (5.7%) died, with three of the deaths being noncardiac. Eight patients (11.4%) also experienced major adverse cardiac events, and six (8.6%) required target vessel revascularization. The crush technique was associated with a lower rate of target lesion failure than the noncrush technique (0% vs. 14%, p=0.03). Furthermore, patients with one- to two-vessel disease had lower rates of target lesion failure than those with three-vessel disease (2.5% vs. 16.7%, p=0.048). Other variables, such as the Syntax score and the lesion site (distal and nondistal left main disease), did not appear to affect target lesion outcomes. Conclusions: In our center, the stenting procedure for uLMCAD resulted in favorable outcomes during hospitalization and at the long-term follow-up, comparable to the results of large clinical trials.

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