Plants have been used for many healing aims since outdated times, and to this day, many essential pharmaceutical dosage forms originated from herbal products. The utilization of herbal products recognized by therapeutic agents in modern healthcare systems has increased over the past two decades. The present biological screening study employed reference methods to estimate Pelargonium graveolens four extracts from the Nablus governorate in Palestine. The outcomes affirmed that the four extracts of the P. graveolens plant have potent antioxidant activity compared with Trolox. The aqueous extract has very potent activity, followed by acetone extract in comparison with Trolox (((s)-(-)-6 hydroxy -2, 5, 7, 8-tetramethychroman- 2-carboxylic acid) with half maximal inhibitory concentration (IC50)doses of 2.29±0.03, 6.48±0.71and 2.88±0.15 µg/ml, respectively. Besides, all the current plant four extracts have α-amylase inhibitory activity in a dose-dependent manner. The results showed that the aqueous extract has potent anti-α-amylase inhibitory activity with an IC50 value of 20.89±0.98 µg/ml, followed by acetone extract with an IC50 value of 29.51±0.74 µg/ml, compared with the positive control Acarbose which has an IC50 value of 28.84±1.28 µg/ml. Based on the results of this study, herbal formulations with P. graveolens aqueous extract have much potential for treating disorders caused by oxidative stress and diabetes.

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