As we see in the community, environment, and daily life, bacterial, microbial, and viral infection creates the severe problem. The medical field is continuously worried about the treatment of infections caused by the microorganism. Day by day, the microorganism in nature becomes stronger and gains more susceptibility to major infections. The researcher continuously works on the development of new antibiotic to break infectivity of the microorganism. But bacteria have the characteristic to adapt in a new environment by generating resistance. Many antibiotics since the discovery of penicillin work on the effects of bacteria for a short duration of time, and after that the bacteria start mutating themselves to overcome the effect of antibiotic. That stage is called antibiotic resistance. At this stage, antibiotic lose their ability to show the effect. The bacteria that show a positive response to gram stain and a negative response to gram stain both seem to be infectious. A resistant bacteria like MRSA becomes more resistant due to the constant mutation of the gene and is susceptible to causing various life-threatening infections. The antibiotics used to treat infection show a less effect at the time of treatment. The review focuses on the problems related to antibiotic resistance and its probable solution by using the derivatives of standard drugs to Methicillin resisted Staphylococcus aureus (MRSA) bacteria, based on MIC study reports. The information collected by referring various open-source databases such as PubMed, Chem Spider, ZINC, Google Scholar, ScienceDirect etc. from year 2005-2022.

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