Environmental exposure to toxic heavy metals remains one of the main serious global health concerns. The objective of this study was to determine if daily supplementation with ascorbic acid for 4 weeks could lower chicken liver cadmium concentration after intentionally exposing hens to cadmium sulfate for 1 week. Normal mix-breed adult broiler chickens (N = 24) were used in this study. The baseline liver cadmium concentration was determined using a graphite furnace atomic absorption spectrophotometer. Each chicken then received 200 mg/kg/day cadmium sulfate and 500 mg/kg/day ascorbic acid mixed with water and feedstuff for 1 week and liver cadmium concentrations were determined. A group of chicken (n = 6) received 500 mg/kg/day ascorbic acid and another group (n = 6) did not receive ascorbic acid. The baseline of liver cadmium level was 4.63 (¬± 0.41) ÔÅ≠g/g. At the end of week 1, the liver cadmium concentration significantly increased to 60.9 (¬± 40.1) ÔÅ≠g/g (p-value < 0.01). Daily supplementation with ascorbic acid for 4 week lowered the liver cadmium concentration to 20.2 (¬± 13.7) ÔÅ≠g/g (p-value < 0.05). Supplementation with ascorbic acid could accelerate reduction of cadmium concentration in poultry liver after intentional exposure.
Shawahna, Ramzi; Zyoud, Ahed; Makhlof, Mohammad; Abu Hilal, Bilal; Hameedi, Saba; Sawafta, Omnia; Imad, Ruba; Su'bi, Amani; and Hilal, Hikmat S.
"Sub-chronic ascorbic acid supplementation accelerates reduction of liver cadmium levels in broiler chicken,"
Palestinian Medical and Pharmaceutical Journal: Vol. 3:
1, Article 1.
Available at: https://pmpj.najah.edu/journal/vol3/iss1/1